The overall aim is to assess changes in biochemical markers with changes in disease progression, and with treatment, in rheumatoid arthritis, osteoarthritis and psoriatic arthritis.The project consists of several sub-projects: I Pro-inflammatory markers in paired samples from blood and synovial fluid from affected joint – How do these correlate to clinical assessments. II Pro-inflammatory activity of ex-vivo explants of synovial membrane from site-specific biopsies from inflamed joint – How do these correlate to clinical assessments. III Study comparing changes in ultrasound (US) Doppler with changes in plasma Vascular Endothelial Growth Factor (VEGF) and IL-6 in patients with rheumatoid arthritis treated with anti-TNF-α.
Else Marie Bartels
’Honorable Senior Researcher
The Biochemistry and Physiology Laboratory
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